The cardiac conduction system (CCS) comprises a heterogeneous network of cells that orchestrate the generation and propagation of electrical impulses to coordinate the heartbeat. Disorders of the CCS have been implicated as the site of initiation of many inherited and acquired forms of cardiac arrhythmias, heart block, and sudden cardiac arrest. Read More »
AAVs are able to safely and efficiently deliver genes to mammalian cells and are thus at the forefront of academic research and therapeutic applications. AAVs expressing fluorescent proteins, such as GFP, provide a powerful imaging biomarker for AAV transduction. Different AAV serotypes exhibit different cellular tropism, many of which have yet to be characterized.CFT technology is capable of determining tissue specificity of AAV serotypes across entire animals by imaging AAV mediated fluorescence in 3D. Read More »
The use of various modalities and probes to evaluate a single target can help better understand the target. To evaluate the correlation between three different agents an immunocompromised mouse is intracranially inoculated with GL26-luc2 cells in the right hemisphere of the brain. The subject is imaged with a T1-weighted MR sequence with Gadolinium contrast enhancement. The subject was also is intravenously administered indocyanine green (ICG) and Angiosense680Ex. Read More »
Tumor associated macrophages (TAM) play a key role in tumor growth and metastasis. Macrophages play a role in the immune response, and macrophage recruitment to tumors has been shown to promote tumor invasiveness and metastasis and is associated with poor prognosis. By using v-sense and CFT we are able to investigate macrophage populations with tumor environments.